There are 3 ways for endpoint to get client cert from ISE internal CA
1. Going through BYOD onboarding
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Login2. Over AnyConnect VPN and SCEP
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Login3. Over certificate provisioning portal
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LoginIf you are dealing with large number of endpoint, I would suggest looking into MDM. Some MDM like Meraki System Manager has built-in CA that you can use to generate client cert with much simpler process than the three methods described above.