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I can't see how using 10G interfaces on an ISE appliance would affect a use of certificate so you should be fine.

In the Firepower lab, there is actually a lab router in front of it that connects to the internet. You can deploy Firepower in several modes but routed mode is the most common. You may or may not put a router in front of it depending on requirements and size of your deployment. In a Data center, you will most likely have a dedicated internet router. Hope this helps.

Pre-filter is like an interface ACL. It can only match IP/Port/Protocol and is stateless so it should only be used to match simple traffic and has rules that are fairly static.

For ACP, traffic is matched by zone pair first so their orders do not really matter. Within the same zone pair, more specific rules should go to the top. ACP is always stateful.